Which substance is associated with the release of endorphins?

The association of opiates with the release of endorphins is well-established in both scientific literature and clinical practice. Opiates, such as morphine and heroin, mimic the body's natural pain-relieving chemicals called endorphins. When opiates bind to the same receptors in the brain that are targeted by endorphins, it enhances the pain relief and pleasurable sensations, leading to the euphoric effects commonly associated with these substances. This mechanism is significant in understanding why individuals might misuse opiates, as the increased endorphin release can lead to feelings of well-being and relief from pain, making these substances highly addictive.

In contrast, caffeine primarily affects neurotransmitters like adenosine and does not significantly impact endorphin release. Hallucinogens focus more on serotonin receptors, producing altered perceptions, while stimulants like cocaine and amphetamines enhance dopamine release, markedly differing in their effects and mechanisms from opiates. These differences emphasize why opiates stand out as the substance most closely linked to endorphin release.