What significant side effect may occur with Disulfiram if alcohol is ingested?

Disulfiram, commonly known by the brand name Antabuse, is a medication used to support the treatment of chronic alcoholism by discouraging the consumption of alcohol. When a person takes Disulfiram and subsequently ingests alcohol, they experience a range of unpleasant physical reactions. These reactions are the result of a disulfiram-alcohol interaction, leading to symptoms such as flushing, nausea, vomiting, palpitations, and hypotension.

The mechanism behind this is that Disulfiram inhibits the enzyme acetaldehyde dehydrogenase, which is responsible for metabolizing acetaldehyde, a substance produced when alcohol is consumed. When alcohol is present in the system, acetaldehyde builds up, leading to the aforementioned distressing symptoms. This serves as a strong deterrent against drinking, reinforcing the individual's motivation to avoid alcohol.

In contrast, enhanced cravings, serious withdrawal symptoms, and rapid weight gain are not typical or direct side effects associated with the use of Disulfiram in the context of alcohol consumption. The primary purpose of Disulfiram is to foster an aversion to alcohol, making option C the only accurate representation of the consequence of alcohol use while on this medication.