What neurotransmitter is primarily influenced by stimulants?

Stimulants primarily influence dopamine, which is a key neurotransmitter in the brain's reward pathway. When stimulants such as cocaine and amphetamines are consumed, they increase the release of dopamine or inhibit its reuptake, leading to enhanced feelings of pleasure and increased motivation. This powerful effect on dopamine is associated with the characteristic feelings of euphoria and increased energy that users often experience.

While stimulants can also impact norepinephrine to some extent, the primary effect and the most significant association with stimulants occurs through the dopamine system. The other neurotransmitters listed—serotonin and GABA—play roles in mood regulation and inhibitory functions, respectively, but they are not primarily targeted by stimulant drugs. Stimulants are more closely tied to the modulation of dopamine release and its related effects.