What causes individuals to experience a 'high' from drugs?

The experience of a 'high' from drugs is primarily caused by their effect on neurotransmitters. When drugs enter the body, they interact with the brain's chemical messengers, which are responsible for transmitting signals between nerve cells. Many substances affect neurotransmitter systems such as dopamine, serotonin, and endorphins, which are linked to feelings of pleasure, reward, and mood regulation.

For example, drugs that increase dopamine levels can lead to heightened sensations of euphoria, which individuals often describe as a 'high.' This neurochemical interaction alters normal brain function, resulting in intense emotional and physical responses that contribute to the overall experience and addictive potential of the substance.

Although the drugs themselves and the dosage taken can influence the intensity of the high, it is the specific biochemical interaction between the drug and neurotransmitters that is the fundamental cause of the euphoric sensations experienced. Similarly, while the duration of use can lead to changes in tolerance or dependency, it ultimately ties back to how those neurotransmitters are affected over time. Understanding these interactions is crucial for recognizing the physiological underpinnings of addiction and its effects on behavior.