What active chemical in marijuana is primarily responsible for its psychoactive effects?

The primary psychoactive component in marijuana is THC, or delta-9-tetrahydrocannabinol. When marijuana is consumed, THC binds to cannabinoid receptors in the brain, particularly those associated with pleasure, memory, thinking, coordination, and time perception. This interaction is what leads to the characteristic effects of marijuana usage, such as the "high" sensation, altered sensory perception, and changes in mood and cognition.

In contrast, CBD (cannabidiol) is another compound found in marijuana that does not produce psychoactive effects but is often credited with potential therapeutic benefits, such as reducing anxiety or inflammation. CP 47,497 is a synthetic cannabinoid that is much less well-known and studied, while Alpha-PVP is a synthetic stimulant unrelated to the psychoactive effects typically associated with marijuana. Therefore, while these other substances may contribute to the broader discussion around cannabis and its effects, THC is the primary chemical responsible for the psychoactive experience commonly associated with marijuana use.